A convenient total synthesis of (Z)-12-tetradecenyl acetate (1a) and (E)-12-tetradecenyl acetate (1b), which are the sex pheromones\nof Ostrinia furnacalis (Guen´ee), has been achieved. The target mixture molecules, of a cis-to-trans-isomer ratio of 27 to 73, were\nsynthesized in 40% overall yield and through [13C + 1C] synthetic strategy in five steps from commercially available and cheap\nindustrial brassylic acid as key starting material. The electroantennogram (EAG) responses of synthetic sex pheromone to ACB\nmale moths were conducted.The results showed that the target mixturemolecules were found to have a good activity and displayed\nsignificantly stronger EAG responses ranging from 10 to 1000 ... and the optimized stimulating dosage of the activity of synthetic\nsex pheromone to ACB males is 10... Compared with the existing routes, this synthetic approach is operationally simple, goodyielding,\nand cost-effective, which could serve as a basis for developing the techniques of sex pheromone mass trapping or mating\ndisruption and providing an environmentally benign method to control ACB pests.
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